Blar i forfatter "Edholm, Eva-Stina Isabella"

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    • Critical Role of an MHC Class I-Like/Innate-Like T Cell Immune Surveillance System in Host Defense against Ranavirus (Frog Virus 3) Infection 

      Edholm, Eva-Stina Isabella; De Jesus Andino, Francisco; Yim, Jinyeong; Woo, Katherine; Robert, Jacques (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-06)
      Besides the central role of classical Major Histocompatibility Complex (MHC) class Ia-restricted conventional Cluster of Differentiation 8 (CD8) T cells in antiviral host immune response, the amphibian <i>Xenopus laevis</i> critically rely on MHC class I-like (mhc1b10.1.L or XNC10)-restricted innate-like (i)T cells (iVα6 T cells) to control infection by the ranavirus Frog virus 3 (FV3). To complement ...

    • Distinct Host–Mycobacterial Pathogen Interactions between Resistant Adult and Tolerant Tadpole Life Stages of Xenopus laevis 

      Rhoo, Kun Hyoe; Edholm, Eva-Stina Isabella; Forzan, Maria J; Khan, Adil Mahboob; Waddle, Anthony W; Pavelka, Martin S; Robert, Jacques (Journal article; Tidsskriftartikkel, 2019-11-15)
      <i>Mycobacterium marinum</i> is a promiscuous pathogen infecting many vertebrates, including humans, whose persistent infections are problematic for aquaculture and public health. Among unsettled aspects of host–pathogen interactions, the respective roles of conventional and innate-like T (iT) cells in host defenses against <i>M. marinum</i> remain unclear. In this study, we developed an infection ...

    • Impacts of the MHC class I-like XNC10 and innate-like T cells on tumor tolerance and rejection in the amphibian Xenopus 

      Banach, Maureen; Edholm, Eva-Stina Isabella; Gonzalez, Xavier; Benraiss, Abdellatif; Robert, Jaques (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
      The conditions that lead to antitumor or protumor functions of natural killer T (NKT) cells against mammalian tumors are only partially understood. Therefore, insights into the evolutionary conservation of NKT and their analogs—innate-like T (iT) cells—may reveal factors that contribute to tumor eradication. As such, we investigated the amphibian <i>Xenopus laevis</i> iT cells and interacting MHC ...

    • Microbial danger signals control transcriptional induction of distinct MHC class I L lineage genes in Atlantic salmon 

      Svenning, Steingrim; Gondek-Wyrozemska, Agata T; van der Wal, Yorick Andreas; Robertsen, Børre; Jensen, Ingvill; Jørgensen, Jorunn B; Edholm, Eva-Stina Isabella (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-11)
      Antigen processing and presentation by major histocompatibility complex (MHC) molecules is a cornerstone in vertebrate immunity. Like mammals, teleosts possess both classical MHC class I and multiple families of divergent MHC class I genes. However, while certain mammalian MHC class I-like molecules have proven to be integral in immune regulation against a broad array of pathogens, the biological ...

    • Piscine Orthoreovirus (PRV)-3, but Not PRV-2, Cross-Protects against PRV-1 and Heart and Skeletal Muscle Inflammation in Atlantic Salmon 

      Malik, Muhammad Salman; Teige, Lena Hammerlund; Braaen, Stine; Olsen, Anne Berit; Nordberg, Monica; Amundsen, Marit; Kannimuthu, Dhamotharan; Svenning, Steingrim; Edholm, Eva-Stina Isabella; Takano, Tomokazu; Jørgensen, Jorunn; Wessel, Øystein; Rimstad, Espen; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-06)
      Heart and skeletal muscle inflammation (HSMI), caused by infection with Piscine orthoreovirus-1 (PRV-1), is a common disease in farmed Atlantic salmon (Salmo salar). Both an inactivated whole virus vaccine and a DNA vaccine have previously been tested experimentally against HSMI and demonstrated to give partial but not full protection. To understand the mechanisms involved in protection against HSMI ...